The chemistry of isoindole natural products

The chemistry of isoindole natural products

This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, m...

Natural products chemistry in the third millennium

The main directions of Natural Products Chemistry in the Third Millennium are summarized.

Neurotrophic natural products: chemistry and biology.

Neurodegenerative diseases and spinal cord injury affect approximately 50 million people worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous system growth factors, that is, neurotrophins, are a potential solution to these disorders, since they could promote nerve regeneration. An average of 500 publications per year attests to the significance of neurotro...

Recent advances in the chemistry of natural products.

In this lecture, an account is presented of the high points in the progress towards the synthesis of vitamin B12 made during 1968—1970 in the collaborative programme carried out at the Eidgenössische Technische Hochschule in Zurich and in Cambridge at Harvard, under the leadership of Albert Eschenmoser and the lecturer. The point of furthest advance is represented by the obtention by total synt...

screening plants for bioactive natural products, using ecological chemistry observations